What this is
This page is your trust stack: everything we know (and don't know) about kanna, based on current research. We believe in transparency, evidence, and responsible use. No hype, no medical claims—just clear information so you can make informed decisions.
Kanna (Sceletium tortuosum) is a South African succulent that has been used traditionally for centuries. Modern research has identified key mechanisms: serotonin reuptake inhibition (SRI) and PDE4 inhibition, which help explain its mood-supporting and cognitive effects. Studies show it reduces amygdala reactivity to stress and supports sustainable neurotransmitter release without the crash (Gericke & Viljoen, 2008; Terburg et al., 2013; Coetzee et al., 2016).
Our goal is to help you understand what kanna is, how it works in your body, what the research says, and how to use it safely. We cite the studies we reference, acknowledge what we don't know yet, and emphasize responsible use—because honest information builds trust.
Science in 5 bullets
Mechanisms: Kanna acts as a serotonin reuptake inhibitor (SRI) and PDE4 inhibitor. Research shows mesembrine-type alkaloids inhibit serotonin reuptake, similar to some antidepressants but with a gentler profile. PDE4 inhibition increases cAMP levels, supporting cognitive function and mental clarity (Gericke & Viljoen, 2008; Harvey et al., 2011).
Standardization matters: Kanna contains multiple alkaloids (mesembrine, mesembrenone, Δ7-mesembrenone). The profile and concentration vary significantly in raw plant material. Our high-mesembrine extract is standardized to ensure consistent potency and effects—this is why quality matters (Gericke & Viljoen, 2008; Smith & Jackson, 2021).
Bioavailability and onset: Oral capsules typically take 30–60 minutes to feel effects, with peak effects at 60–90 minutes. Effects typically last 3–6 hours. Sublingual or chewable forms may have faster onset. Individual responses vary based on metabolism and sensitivity (Terburg et al., 2013).
Dose-response: Kanna often shows "less is more" dynamics. Research suggests VMAT2 modulation supports sustainable neurotransmitter release without the crash associated with synthetic stimulants. Higher doses don't always mean stronger effects, and some people are more sensitive than others (Coetzee et al., 2016).
Safety considerations: Kanna may interact with SSRIs, MAOIs, and other medications that affect serotonin. Research shows it reduces amygdala reactivity and stress-induced cortisol, but it's not recommended during pregnancy or breastfeeding. People with anxiety disorders, blood pressure issues, or other health conditions should consult a healthcare provider (Terburg et al., 2013; Harvey et al., 2011).
Evidence Notes
- ✅ Gericke & Viljoen (2008) - SRI mechanism, mesembrine identification
- ✅ Harvey et al. (2011) - PDE4 inhibition, cognitive effects
- ✅ Terburg et al. (2013) - Timing (30-60 min onset, 60-90 min peak, 3-6 hour duration), amygdala reactivity, stress response
- ✅ Coetzee et al. (2016) - VMAT2 modulation, sustainable release
- ✅ Smith & Jackson (2021) - Comprehensive review of mechanisms and safety
- Note: Quality testing standards are industry best practices (third-party testing for identity, heavy metals, microbial, residual solvents)
What helps / what backfires
What helps
- Using standardized, tested extracts
- Starting with low doses and going slow
- Understanding your individual response
- Consulting healthcare providers if you have health conditions
- Being aware of potential interactions
- Using quality products from trusted sources
What backfires
- Using unstandardized or untested products
- Starting with high doses
- Ignoring potential interactions with medications
- Using during pregnancy or breastfeeding without medical guidance
- Expecting instant or guaranteed effects
- Using kanna to replace medical care
Responsible Use
Know your starting point
Understand your health status, medications, and any conditions that might affect how you respond. When in doubt, consult a healthcare provider.
Choose quality products
Look for standardized extracts from trusted sources. Check for third-party testing (identity, heavy metals, microbial, residual solvents).
Start low, go slow
Begin with the lowest recommended dose. Give it time to work (30–60 minutes for oral). Don't increase dose quickly—individual responses vary.
Pay attention to your response
Notice how you feel. What helps? What doesn't? Keep a simple log if helpful. Everyone's response is different.
Use responsibly
Kanna is a tool, not a cure. Use it as part of a broader approach to wellness. Don't use it to replace medical care or therapy.
Frequently Asked Questions
Kanna is not a medical treatment and should not replace medical care. If you have health conditions, take medications, or are pregnant or breastfeeding, consult a healthcare provider before using kanna. This information is for educational purposes only and is not medical advice.